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| Benztropine
(Cogentin) Benztropine (Cogentin®) is an anticholinergic drug principally used for the treatment of: * Drug-induced parkinsonism, akathisia and acute dystonia; * Parkinson disease; and * Idiopathic or secondary dystonia. Indications It is used in patients with schizophrenia to reduce the side effects of antipsychotic treatment, such as parkinsonism and akathisia. Benztropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor but not rigidity or bradykinesia. Benztropine is also sometimes used for the treatment of dystonia, a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face. Side effects These are principally anticholinergic: * Dry mouth * Blurred vision * Cognitive changes * Constipation * Urinary retention * Tachycardia * Anorexia * Psychosis (usually in overdose) Some studies suggest that use of anticholinergics increases the risk of tardive dyskinesia, a long-term side effect of antipsychotics. Other studies have found no association between anticholinergic exposure and risk of developing tardive dyskinesia. |