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Amisulpride

Amisulpride (brand-name Solian®) is an antipsychotic drug sold by Sanofi laboratories. Amisulpride is a selective dopamine antagonist. Its dosage ranges from 200 to 1200 mg/day. Lower doses (e.g. less than 50mg) have the opposite effect and actually increase dopamine transmission. For this reason, it is sometimes used off-label in the treatment of clinical depression in low doses and for psychosis in higher doses. As for now, amisulpride is not approved by the FDA for use in the United States.

Side effects

Parkinsonism, nausea, weight gain, and less commonly QT interval prolongation (which can lead to serious heart arrhythmias).


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