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Passion Flower Medical uses Passion flower has a long history of use among Native Americans, in both North and Central America. It is used to treat insomnia, hysteria, and epilepsy, and is also valued for its painkilling properties. It has been found to contain beta-carbolines in the harmala family, an MAOI which has Anti-depressant properties and hallucinogenic properties at higher doses, typically used in conjunction with DMT to facilitate oral consumption.