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Hyperforin

Hyperforin is one of the principal constituents identified in St John's wort. Hyperforin is a prenylated phloroglucinol believed to be the main active constituent responsible for its antidepressant effects. (Barnes et al., 2002) Hyperforin has been shown to inhibit the uptake of 5-HT, dopamine, noradrenaline, GABA and glutamate. (Chatterjee et al., 1998)